Issue 16, 2024, Issue in Progress
From the journal:

RSC Advances

Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides†

Xiao-Fang Zhang,a   Jiao-Xian Du,a   Si-Qiong Teng,a   Hui Liu,a   Juan He,*ab   Tao Feng ORCID logo *abc  and  Ji-Kai Liu*ab  

* Corresponding authors

a School of Pharmaceutical Sciences, South-Central Minzu University, 182 Minzu Road, Wuhan 430074, P.R. China
E-mail: 2015048@mail.scuec.edu.cn, tfeng@mail.scuec.edu.cn, liujikai@mail.scuec.edu.cn

b National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan 430074, China

c College of Life Science, South-Central Minzu University, Wuhan 430074, China

Abstract

Carpesabrolide A (1), featuring an unprecedented fumaric acid–guaiane sesquiterpenoid hybrid, has been isolated from the folk medicinal plant Carpesium abrotanoides. The structure with absolute configuration has been established by spectroscopic methods and single crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1 is proposed. Compound 1 shows significant anti-inflammatory activity by inhibiting NO production with an IC50 value of 2.7 μM.

Graphical abstract: Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D4RA00292J
Article type
Paper
Submitted
11 Jan 2024
Accepted
28 Mar 2024
First published
05 Apr 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 11002-11006

Permissions

Request permissions

Carpesabrolide A, a novel meroterpenoid with anti-inflammatory activity from Carpesium abrotanoides

X. Zhang, J. Du, S. Teng, H. Liu, J. He, T. Feng and J. Liu, RSC Adv., 2024, 14, 11002 DOI: 10.1039/D4RA00292J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements