Issue 10, 2024

Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[cd]indole-2(1H)-ketone

Abstract

6-Nitrobenzo[cd]indole-2(1H)-ketone (compound C2) exhibits an excellent germicidal effect against methicillin-resistant Staphylococcus aureus (MRSA). Mechanism studies show that C2 induces ROS over-production, cell membrane damage, and ATP and virulence factor down-regulation in bacteria. More importantly, C2 can inhibit biofilm formation and accelerate wound healing in a mouse infection model induced by MRSA.

Graphical abstract: Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[cd]indole-2(1H)-ketone

Supplementary files

Article information

Article type
Communication
Submitted
13 Nov 2023
Accepted
06 Feb 2024
First published
14 Feb 2024

J. Mater. Chem. B, 2024,12, 2481-2485

Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[cd]indole-2(1H)-ketone

H. Qin, L. Li, S. Chen, X. Han, R. Min, Y. Guo, T. Liu and C. Zhao, J. Mater. Chem. B, 2024, 12, 2481 DOI: 10.1039/D3TB02686H

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