Issue 1, 2024
From the journal:

RSC Advances

Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells

Hui Yu,a   Xinyi He,a   Xiaoya Gu,a   Yuemin Hou,a   Haoyi Zhao,a   Li Gao,a   Ruifang An*a  and  Jia Wang ORCID logo *a  

* Corresponding authors

a Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China
E-mail: anruifang@xjtu.edu.cn, wangjia_80@163.com

Abstract

Choriocarcinoma can be cured by chemotherapy, but this causes resistance and severe side effects that bring about physical and psychological consequences for patients. Therefore, there is still an urgent need to find other alternative minimally invasive therapies to halt the progression of choriocarcinoma. Novel carbon-coated selenium nanoparticles (C–Se) were successfully synthesized for choriocarcinoma photothermal therapy. C–Se combined with near-infrared laser irradiation can inhibit the proliferation of human choriocarcinoma (JEG-3) cells and induce cell apoptosis. C–Se killed cells and produced ROS under near-infrared laser irradiation. Finally, the therapeutic mechanism of C–Se + laser was explored showing that C–Se + laser influenced numerous biological processes. Taken together, C–Se exhibited significant potential for choriocarcinoma photothermal therapy.

Graphical abstract: Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells

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Article information

DOI
https://doi.org/10.1039/D3RA07085A
Article type
Paper
Submitted
18 Oct 2023
Accepted
27 Nov 2023
First published
02 Jan 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 640-649

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Carbon-coated selenium nanoparticles for photothermal therapy in choriocarcinoma cells

H. Yu, X. He, X. Gu, Y. Hou, H. Zhao, L. Gao, R. An and J. Wang, RSC Adv., 2024, 14, 640 DOI: 10.1039/D3RA07085A

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