Issue 40, 2023, Issue in Progress

Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction

Abstract

Applying a multistep approach, novel indolin-2-ones (IND) that possess an arylidene motif have been synthesized. Eight compounds were chosen for different biological tests (antimicrobial and cytotoxicity). IND containing 2-thienyl (4h) fragment have been found to exhibit good antimicrobial activity against B. cereus. Molecules that have 3-aminophenyl (4d) or 2-pyridyl (4g) groups have shown the best antifungal activities against all tested fungi. These compounds have also been noticed as promising pharmaceuticals against MCF-7 cancer cell lines. Experimental outcomes from the investigation of the interaction of 4d with DNA implied its moderate binding to DNA (KSV = 1.35 × 104 and 3.05 × 104 M−1 for EB and Hoechst binder, respectively). However, considerably stronger binding of 4d to BSA has been evidenced (Ka = 6.1 × 106 M−1). In summary, IND that contains m-aminobenzylidene fragment (4d) exhibits a good dual biological activity making it a promising candidate for further investigation in the drug discovery sector.

Graphical abstract: Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction

Supplementary files

Article information

Article type
Paper
Submitted
24 Jul 2023
Accepted
17 Sep 2023
First published
25 Sep 2023
This article is Open Access
Creative Commons BY license

RSC Adv., 2023,13, 28139-28147

Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction

S. N. A. Bukhari, T. G. Alsahli, H. Ejaz, N. Ahmed, W. Ahmad, M. A. Elsherif, N. H. Alotaibi, K. Junaid and N. Janković, RSC Adv., 2023, 13, 28139 DOI: 10.1039/D3RA04997C

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