K2S2O8-mediated direct C–H heteroarylation/hydroxylation of indolin-2-ones with quinoxalin-2(1H)-ones†
Hui
Qin, 
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Yiwen
Zhang
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and
‡*ad
Yiwen
Zhang
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and
Abstract
Herein, a K2S2O8-mediated direct heteroarylation and hydroxylation reaction between quinoxalin-2(1H)-ones with a C(sp2)–H bond and indolin-2-ones with a C(sp3)–H bond via an oxidative cross-coupling reaction has been reported. We have successfully established a feasible and concise reaction system that represents the first example of free-radical-promoted heteroarylation and hydroxylation reaction on the C-3 position of oxindole. A series of 3-substituted 3-hydroxyoxindoles are obtained in 0–83% yield using this methodology.
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