Issue 7, 2024
From the journal:

Chemical Communications

Impact of loop length and duplex extensions on the design of hybrid-type G-quadruplexes†

Jagannath Jana,a   Yoanes Maria Vianney ORCID logo a  and  Klaus Weisz ORCID logo *a  

* Corresponding authors

a Institut für Biochemie, Universität Greifswald, Felix-Hausdorff Str. 4, Greifswald D-17489, Germany
E-mail: weisz@uni-greifswald.de
Tel: +49 3834 420 4426

Abstract

A G-rich core sequence G3-TCA-G3-T1,2-G3-T1,2-G3 can be designed to fold into a parallel or into two different (3+1) hybrid-type G-quadruplexes, among them an elusive topology with one lateral followed by two propeller loops. Favored folds can be rationalized based on the number of intervening thymidines and on additional complementary flanking sequences.

Graphical abstract: Impact of loop length and duplex extensions on the design of hybrid-type G-quadruplexes

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Article information

DOI
https://doi.org/10.1039/D3CC05625B
Article type
Communication
Submitted
15 Nov 2023
Accepted
17 Dec 2023
First published
18 Dec 2023

Chem. Commun., 2024,60, 854-857

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Impact of loop length and duplex extensions on the design of hybrid-type G-quadruplexes

J. Jana, Y. M. Vianney and K. Weisz, Chem. Commun., 2024, 60, 854 DOI: 10.1039/D3CC05625B

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