Issue 4, 2024

PhpC modulates G-quadruplex-RNA landscapes in human cells

Abstract

Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.

Graphical abstract: PhpC modulates G-quadruplex-RNA landscapes in human cells

Supplementary files

Article information

Article type
Communication
Submitted
19 Oct 2023
Accepted
05 Dec 2023
First published
05 Dec 2023

Chem. Commun., 2024,60, 424-427

PhpC modulates G-quadruplex-RNA landscapes in human cells

J. Mitteaux, S. Raevens, Z. Wang, M. Pirrotta, I. E. Valverde, R. H. E. Hudson and D. Monchaud, Chem. Commun., 2024, 60, 424 DOI: 10.1039/D3CC05155B

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