A novel porous nanocomposite composed of hydroxyapatite nanorods (HAP), a MIL-101(Fe) metal–organic framework, and Fe₃O₄ nanoparticles was successfully fabricated in this work. The magnetic HAP/MIL-101(Fe)/Fe₃O₄ ternary nanocomposite was identified by various techniques, namely FT-IR spectroscopy, XRD, Raman spectroscopy, SEM, EDX, TEM, BET specific surface area, zeta potential, and VSM measurements. Tetracycline (TC) and ciprofloxacin (CIP) aqueous solutions were used to evaluate the adsorption performance of the resulting HAP/MIL-101(Fe)/Fe₃O₄ composite. The adsorption rate and capacity of HAP/MIL-101(Fe)/Fe₃O₄ were increased as compared with HAP, MIL-101(Fe), and HAP/MIL-101(Fe) samples due to the increased attraction. The influence of initial drug concentration, adsorbent dosage, temperature, and pH on the adsorption process was investigated. The results showed that the removal efficiencies of HAP/MIL-101(Fe)/Fe₃O₄ for TC and CIP were 95% and 93%, under the determined optimum conditions: pH of 7, drug concentration of 50 mg L⁻¹, adsorbent dosage of 30 mg, and temperature of 25 °C. The maximum adsorption capacities of HAP/MIL-101(Fe)/Fe₃O₄ for TC and CIP were 120.48 mg g⁻¹ and 112.35 mg g⁻¹, respectively. Reusability of the prepared nanocomposite was easily achieved up to three times without significant change in its structure. As a result, the synthesized magnetic nanocomposite can be reused as a suitable absorbent for TC and CIP removal from aqueous solutions.