Issue 37, 2022, Issue in Progress
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RSC Advances

Simultaneous detection of acetaminophen, catechol and hydroquinone using a graphene-assisted electrochemical sensor†

Guofang Wang,‡a   Siyi Zhang,‡a   Qinyu Wu,‡a   Jingzhi Zhu,a   Suhua Chen,c   Yuanyuan Lei,a   Yanmei Li,a   Haomin Yi,a   Liyin Chen,d   Zi-Qi Shi*b  and  Yi Xiao ORCID logo *ad  

* Corresponding authors

a Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha 410013, Hunan, China
E-mail: njcpuxy4936@163.com

b Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China
E-mail: shiziqi47@126.com

c Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, Hunan, China

d John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

Abstract

Simple, rapid and sensitive analysis of drug-derived pollutants is critically valuable for environmental monitoring. Here, taking acetaminophen, hydroquinone and catechol as a study example, a sensor based on an ITO/APTES/r-GO@Au electrode was developed for separate and simultaneous determination of phenolic pollutants. ITO electrodes that are modified with 3-aminopropyltriethoxysilane (APTES), graphene (GO) and Au nanoparticles (Au NPs) can significantly enhance the electronic transport of phenolic pollutants at the electrode surface. The redox mechanisms of phenolic pollutants include the electron transfer with the enhancement of r-GO@Au. The modified ITO electrode exhibits excellent electrical properties to phenolic pollutants and a good linear relationship between ECL intensity and the concentration of phenolic pollutants, with a limit of detection of 0.82, 1.41 and 1.95 μM, respectively. The separate and simultaneous determination of AP, CC and HQ is feasible with the ITO/APTES/r-GO@Au electrode. The sensor shows great promise as a low-lost, sensitive, and rapid method for simultaneous determination of drug-derived pollutants.

Graphical abstract: Simultaneous detection of acetaminophen, catechol and hydroquinone using a graphene-assisted electrochemical sensor

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Article information

DOI
https://doi.org/10.1039/D2RA03900A
Article type
Paper
Submitted
24 Jun 2022
Accepted
11 Aug 2022
First published
22 Aug 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 23762-23768

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Simultaneous detection of acetaminophen, catechol and hydroquinone using a graphene-assisted electrochemical sensor

G. Wang, S. Zhang, Q. Wu, J. Zhu, S. Chen, Y. Lei, Y. Li, H. Yi, L. Chen, Z. Shi and Y. Xiao, RSC Adv., 2022, 12, 23762 DOI: 10.1039/D2RA03900A

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