Issue 39, 2022, Issue in Progress
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RSC Advances

Optimization of uric acid detection with Au nanorod-decorated graphene oxide (GO/AuNR) using response surface methodology

Hana Safitri,a   Wulan Tri Wahyuni, ORCID logo *ab   Eti Rohaeti,a   Munawar Khalil ORCID logo c  and  Frank Marken ORCID logo d  

* Corresponding authors

a Analytical Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Indonesia
E-mail: wulantriws@apps.ipb.ac.id

b Tropical Biopharmaca Research Center, Institute of Research and Community Empowerment, IPB University, Indonesia

c Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia

d Department of Chemistry, University of Bath, UK

Abstract

A modified glassy carbon electrode (GCE) was developed based on a synthesized graphene oxide (GO) gold nanorod (AuNR) decorated composite (GO/AuNR) for sensitive electrochemical sensing of uric acid (UA). The electrochemical performance of GO/AuNR/GCE for UA detection was investigated employing the differential pulse voltammetry (DPV) technique. Central composite design (CCD) was applied to obtain the optimum composition of the GO and AuNR composite, which provide the highest possible UA oxidation peak current. The optimum composition was obtained at a GO concentration of 5 mg mL−1 and AuNR volume of 10 mL. Under the optimum conditions, GO/AuNR/GCE showed acceptable analytical performance for UA detection with good linearity (concentration range of 10–90 μM) and both a low detection limit (0.4 μM) and quantitation limit (1.0 μM). Furthermore, the proposed sensor exhibits superior stability, reproducibility, and selectivity using ascorbic acid (AA), dopamine (DA), urea, glucose, and magnesium as interferents. Finally, practical use of GO/AuNR/GCE was demonstrated by successfully determining the content of UA in human urine samples with the standard addition approach.

Graphical abstract: Optimization of uric acid detection with Au nanorod-decorated graphene oxide (GO/AuNR) using response surface methodology

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Article information

DOI
https://doi.org/10.1039/D2RA03782C
Article type
Paper
Submitted
20 Jun 2022
Accepted
23 Aug 2022
First published
07 Sep 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 25269-25278

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Optimization of uric acid detection with Au nanorod-decorated graphene oxide (GO/AuNR) using response surface methodology

H. Safitri, W. T. Wahyuni, E. Rohaeti, M. Khalil and F. Marken, RSC Adv., 2022, 12, 25269 DOI: 10.1039/D2RA03782C

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