Enhanced healing process of tooth sockets using strontium-doped TiO2

Jialing Li; Zilu Fan; Min Huang; Yonglin Xie; Zhenju Guan; Jianping Ruan

doi:10.1039/D2RA00341D

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Enhanced healing process of tooth sockets using strontium-doped TiO₂†

Jialing Li,^ab Zilu Fan,^b Min Huang,^b Yonglin Xie,^b Zhenju Guan^b and Jianping Ruan

*^a

Author affiliations

* Corresponding authors

^a College of Stomatology, Department of Preventive Dentistry, Xi'an Jiao Tong University, Xi'an, Shaanxi, People's Republic of China
E-mail: jianpingruan@126.com

^b Nanchong Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, Sichuan, People's Republic of China

Abstract

Prevention of residual ridge resorption is important for tooth socket healing in clinical treatment. As a well known biomaterial, titanium dioxide (TiO₂) has been reported to show desirable bone regeneration capability. On the other hand, strontium plays a role in maintaining normal function in organisms and balancing bone remodeling. Hence, we synthesized strontium-doped titanium dioxide mesoporous nanospheres functionalized with amino-group using diphenyl diisocyanate. After incorporation with segmented polyurethane, the obtained injectable SPU/Sr-TiO₂/MDI nanocomposite adhesive showed satisfactory antibacterial activity and cell nontoxicity. This nanocomposite was used for tooth socket healing, and greatly promoted the formation of new bone tissue in the tooth extraction socket.

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Article information

DOI: https://doi.org/10.1039/D2RA00341D
Article type: Paper
Submitted: 18 Jan 2022
Accepted: 20 May 2022
First published: 15 Jun 2022
This article is Open Access

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RSC Adv., 2022,12, 17817-17820

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Enhanced healing process of tooth sockets using strontium-doped TiO₂

J. Li, Z. Fan, M. Huang, Y. Xie, Z. Guan and J. Ruan, RSC Adv., 2022, 12, 17817 DOI: 10.1039/D2RA00341D

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