Total synthesis of (+)-ent-vetiverianine a via Lewis acid-mediated cyclization†
Shogo
Kamo 
a
and
Kazuyuki
Sugita
*a
a
and
Kazuyuki
Sugita
*a
Abstract
Herein, we describe the first total synthesis of (+)-ent-vetiverianine A, which exhibits a 5/6/6-fused tricyclic structure. The key reactions, including Lewis acid-mediated cyclization, Mukaiyama hydration, enantioselective Shi epoxidation, Birch reduction, and other effective transformations, enabled enantioselective access to (+)-ent-vetiverianine A with the longest linear sequence of 14 steps, and in 12% overall yield.
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