Issue 3, 2023

Catalytic enantioselective desymmetrization of meso-aziridines

Abstract

As a type of readily available small strained-ring heterocycle, meso-aziridines may undergo catalytic desymmetrizing transformations to empower the rapid construction of diverse nitrogen-containing structures bearing contiguous stereocenters, which have great relevance in natural product synthesis, drug development and the design and synthesis of chiral catalysts/ligands for asymmetric catalysis. This review outlines the advances achieved in the catalytic asymmetric desymmetrization of meso aziridines and highlights some promising avenues for further work in this realm.

Graphical abstract: Catalytic enantioselective desymmetrization of meso-aziridines

Article information

Article type
Review Article
Submitted
22 Oct 2022
Accepted
24 Nov 2022
First published
25 Nov 2022

Org. Biomol. Chem., 2023,21, 465-478

Catalytic enantioselective desymmetrization of meso-aziridines

P. Yang and Z. Chai, Org. Biomol. Chem., 2023, 21, 465 DOI: 10.1039/D2OB01935C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements