Catalyst-free electrochemical trifluoromethylation of coumarins using CF3SO2NHNHBoc as the CF3 source

Nannan Cen; Han Wang; YiCheng Zhou; Ruoqu Gong; Dandan Sui; Wenbo Chen

doi:10.1039/D2OB01925F

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Catalyst-free electrochemical trifluoromethylation of coumarins using CF₃SO₂NHNHBoc as the CF₃ source†

Nannan Cen,^a Han Wang,^a YiCheng Zhou,^a Ruoqu Gong,^a Dandan Sui^a and Wenbo Chen

*^ab

Author affiliations

* Corresponding authors

^a Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China
E-mail: wenbochen@shiep.edu.cn

^b CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

An efficient electrochemical trifluoromethylation of coumarins using CF₃SO₂NHNHBoc as the source of the trifluoromethyl group was developed. Under catalyst-free and external oxidant-free electrolysis conditions, a range of 3-trifluoromethyl coumarins were obtained in moderate to good yields. The method could be easily scaled up with moderate efficiency.

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Article information

DOI: https://doi.org/10.1039/D2OB01925F
Article type: Communication
Submitted: 21 Oct 2022
Accepted: 26 Jan 2023
First published: 26 Jan 2023

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Org. Biomol. Chem., 2023,21, 1883-1887

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Catalyst-free electrochemical trifluoromethylation of coumarins using CF₃SO₂NHNHBoc as the CF₃ source

N. Cen, H. Wang, Y. Zhou, R. Gong, D. Sui and W. Chen, Org. Biomol. Chem., 2023, 21, 1883 DOI: 10.1039/D2OB01925F

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Organic & Biomolecular Chemistry