One-pot C–C, C–N, and C–S bond construction for synthesis of 3-sulfenylindoles directly from unactivated anilines involving dual palladium catalysis and mechanistic insights from DFT†
Sumit K.
Rastogi, 
ab
Santosh
Kumar,
ab
Mini Bharati
Ahirwar,
c
Milind M.
Deshmukh,
c
Arun K.
Sinha
*abe
and
Ravindra
Kumar
*ab
ab
Santosh
Kumar,
ab
Mini Bharati
Ahirwar,
c
Milind M.
Deshmukh,
c
Arun K.
Sinha
*abe
and
Ravindra
Kumar
*ab
Abstract
An efficient dual Pd-catalytic system was developed for one-pot synthesis of 3-sulfenylindoles via C–C, C–N and C–S bond construction directly from unactivated 2-iodo(NH)anilines under mild reaction conditions. Furthermore, 3-selenyl/halo/carbon-functionalized indoles were synthesized in good yields and a short reaction time. The synthetic utility of 3-sulfenylindole was also demonstrated. The key role of solvent in palladium catalysis was unravelled by DFT.
Please wait while we load your content...
