Issue 3, 2023
From the journal:

Nanoscale Advances

Zn0.4Mg0.6Fe2O4 nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma†

Liang Chen,‡a   Qingmei Kong,‡b   Mingxing Tian,a   Qian Zhang,b   Chengwan Xia ORCID logo *b  and  Chao Deng*c  

* Corresponding authors

a Department of Oral and Maxillofacial Surgery, Yi Ji Shan Hospital of Wannan Medical College, Wuhu, Anhui, China

b Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, China
E-mail: 2665927917@qq.com

c Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education, School of Stomatology, Wannan Medical College, Anhui, China
E-mail: 20120015@wnmc.edu.cn

Abstract

Hypoxic and acidic environments are the two main components of the microenvironment contributing to the poor efficacy of chemotherapy drugs in the treatment of oral squamous cell carcinoma (OSCC). In this study, we synthesized a series of Zn1–xMgxFe2O4 nanomaterials with enzyme-like properties, including catalase (CAT)-like, peroxidase (POD)-like, and glutathione (GSH)-like activity in an acidic environment. Among them, Zn0.4Mg0.6Fe2O4 performed the best and effectively increased the efficacy of doxorubicin (DOX) chemotherapy for the treatment of OSCC with reduced cardiotoxicity. Therefore, Zn0.4Mg0.6Fe2O4 could serve as a novel chemosensitizer in the treatment of OSCC.

Graphical abstract: Zn0.4Mg0.6Fe2O4 nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma

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Article information

DOI
https://doi.org/10.1039/D2NA00750A
Article type
Paper
Submitted
26 Oct 2022
Accepted
21 Dec 2022
First published
28 Dec 2022
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 851-860

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Zn0.4Mg0.6Fe2O4 nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma

L. Chen, Q. Kong, M. Tian, Q. Zhang, C. Xia and C. Deng, Nanoscale Adv., 2023, 5, 851 DOI: 10.1039/D2NA00750A

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