Issue 99, 2022
From the journal:

Chemical Communications

Riboflavin-catalyzed templated reaction to translate nucleic acid cues into signals of rhodamine derivatives†

Hokyung Kim,a   Hayeon Choi,a   Kyeong Su Min,a   Woo Joo Han,a   Jae Woo Park*a  and  Ki Tae Kim ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Chungbuk National University, Cheongju 28644, Republic of Korea
E-mail: ktkim@chungbuk.ac.kr, Jaewoopark@chungbuk.ac.kr

Abstract

We report a templated reaction for the facile translation of nucleic acid cues into signals of universal rhodamine derivatives based on the riboflavin-catalyzed oxidation of dihydrorhodamine compounds. The rhodamine-signaling operation enabled us to design a highly sequence-selective fluorescent sensor that can detect as little as 500 pM of the target nucleic acid in 90 min or to present a rhodamine antibody that can be further applied to immunoassays.

Graphical abstract: Riboflavin-catalyzed templated reaction to translate nucleic acid cues into signals of rhodamine derivatives

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Article information

DOI
https://doi.org/10.1039/D2CC05447G
Article type
Communication
Submitted
05 Oct 2022
Accepted
15 Nov 2022
First published
15 Nov 2022

Chem. Commun., 2022,58, 13743-13746

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Riboflavin-catalyzed templated reaction to translate nucleic acid cues into signals of rhodamine derivatives

H. Kim, H. Choi, K. S. Min, W. J. Han, J. W. Park and K. T. Kim, Chem. Commun., 2022, 58, 13743 DOI: 10.1039/D2CC05447G

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