Issue 82, 2022
From the journal:

Chemical Communications

Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations†

Claire Welton,‡a   Parth Raval,‡a   Julien Tréboscb  and  G. N. Manjunatha Reddy ORCID logo *a  

* Corresponding authors

a University of Lille, CNRS, Centrale Lille Institut, Univ. Artois, UMR 8181 – UCCS – Unité de Catalyse et Chimie du Solide, Lille, France
E-mail: gnm.reddy@univ-lille.fr

b University of Lille, CNRS, INRAE, Centrale Lille, Univ. Artois, FR 2638 – IMEC – Institut Michel-Eugène Chevreul, Lille, France

Abstract

Chemically assisted swapping of labile protons by deuterons is presented for amino acids, polysaccharides, pharmaceutical compounds, and their solid formulations. Solid-state packing interactions in these compounds are elucidated by 1H–2H isotope correlation NMR spectroscopy (iCOSY). A minuscule concentration of dopamine, 5 wt% or ∼100 μg, in a solid formulation can be detected by 2H NMR at 28.2 T (1H, 1200 MHz) in under a minute.

Graphical abstract: Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations

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Article information

DOI
https://doi.org/10.1039/D2CC04585K
Article type
Communication
Submitted
17 Aug 2022
Accepted
14 Sep 2022
First published
14 Sep 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 11551-11554

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Chemical exchange of labile protons by deuterium enables selective detection of pharmaceuticals in solid formulations

C. Welton, P. Raval, J. Trébosc and G. N. M. Reddy, Chem. Commun., 2022, 58, 11551 DOI: 10.1039/D2CC04585K

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