Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

Ben. J. Tickner; Sanna Komulainen; Sanna Palosaari; Janne Heikkinen; Petri Lehenkari; Vladimir V. Zhivonitko; Ville-Veikko Telkki

doi:10.1039/D1RA07376A

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Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols†

Ben. J. Tickner,

‡^a Sanna Komulainen,‡^a Sanna Palosaari,

^bc Janne Heikkinen,

^b Petri Lehenkari,

^bcd Vladimir V. Zhivonitko

*^a and Ville-Veikko Telkki

*^a

Author affiliations

* Corresponding authors

^a NMR Research Unit, Faculty of Science, University of Oulu, Finland
E-mail: vladimir.zhivonitko@oulu.fi, ville-veikko.telkki@oulu.fi

^b Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Finland

^c Medical Research Center Oulu, Faculty of Medicine, University of Oulu and Oulu University Hospital, Finland

^d Division of Orthopedic Surgery, Oulu University Hospital, Finland

Abstract

Signal amplification by reversible exchange (SABRE) hyperpolarisation is used to enhance the NMR signals of nicotine and acrolein in methanol-d₄ solutions of electronic cigarette aerosols. Consequently, detection of 74 μM nicotine is possible in just a single scan ¹H NMR spectrum. The first example of an aldehyde hyperpolarised using SABRE is demonstrated and we work towards novel real-world applications of SABRE-hyperpolarised NMR for chemical analysis.

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DOI: https://doi.org/10.1039/D1RA07376A
Article type: Paper
Submitted: 04 Oct 2021
Accepted: 15 Dec 2021
First published: 10 Jan 2022
This article is Open Access

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RSC Adv., 2022,12, 1479-1485

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Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

Ben. J. Tickner, S. Komulainen, S. Palosaari, J. Heikkinen, P. Lehenkari, V. V. Zhivonitko and V. Telkki, RSC Adv., 2022, 12, 1479 DOI: 10.1039/D1RA07376A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols†

Abstract

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Hyperpolarised NMR to aid molecular profiling of electronic cigarette aerosols

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