Issue 22, 2021

Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines

Abstract

A selective cyclization of unsaturated barbiturates and amidines promoted by N-bromosuccinimide has been successfully developed to afford a vast variety of 5,4′-imidazolinyl spirobarbiturates in moderate to good yields. The present protocol features broad substrate scope, facile work-up procedure and mild reaction conditions, providing a novel strategy for the highly selective and efficient construction of structurally diverse spiroimidazolines.

Graphical abstract: Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines

Supplementary files

Article information

Article type
Paper
Submitted
16 Mar 2021
Accepted
08 May 2021
First published
10 May 2021

Org. Biomol. Chem., 2021,19, 4978-4985

Chemoselective synthesis of 5,4′-imidazolinyl spirobarbiturates via NBS-promoted cyclization of unsaturated barbiturates and amidines

H. Xu, R. Huang, Z. Shu, R. Hong and Z. Zhang, Org. Biomol. Chem., 2021, 19, 4978 DOI: 10.1039/D1OB00508A

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