Issue 17, 2021
From the journal:

Green Chemistry

Direct para-C–H heteroarylation of anilines with quinoxalinones by metal-free cross-dehydrogenative coupling under an aerobic atmosphere†

Jun Xu,a   Lin Huang,a   Lei He,a   Chenfeng Liang,a   Yani Ouyang,a   Jiabin Shen,a   Min Jianga  and  Wanmei Li ORCID logo *a  

* Corresponding authors

a College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China
E-mail: liwanmei@hznu.edu.cn

Abstract

Herein, a green and efficient metal-free cross-dehydrogenative coupling (CDC) for the direct para-C–H heteroarylation of anilines with quinoxalinones has been described. This reaction is performed in H2O/DMSO (v/v = 2 : 1) using air as the sole oxidant. Various anilines (primary, secondary and tertiary amines) and quinoxalinones are well compatible, affording the corresponding products in moderate-to-good yields. Such a methodology provides an environmentally friendly and efficient alternative for the late-stage modification of nitrogen-containing compounds.

Graphical abstract: Direct para-C–H heteroarylation of anilines with quinoxalinones by metal-free cross-dehydrogenative coupling under an aerobic atmosphere

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Article information

DOI
https://doi.org/10.1039/D1GC01899J
Article type
Paper
Submitted
29 May 2021
Accepted
30 Jul 2021
First published
13 Aug 2021

Green Chem., 2021,23, 6632-6638

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Direct para-C–H heteroarylation of anilines with quinoxalinones by metal-free cross-dehydrogenative coupling under an aerobic atmosphere

J. Xu, L. Huang, L. He, C. Liang, Y. Ouyang, J. Shen, M. Jiang and W. Li, Green Chem., 2021, 23, 6632 DOI: 10.1039/D1GC01899J

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