Issue 43, 2021

Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls

Abstract

A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide.

Graphical abstract: Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2021
Accepted
26 Apr 2021
First published
04 May 2021

Chem. Commun., 2021,57, 5266-5269

Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls

U. S. Ismailani, M. Munch, B. A. Mair and B. H. Rotstein, Chem. Commun., 2021, 57, 5266 DOI: 10.1039/D1CC01016F

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