Issue 7, 2022
From the journal:

Analytical Methods

An origami paper-based analytical device for rapid detection of testosterone in healthcare food†

Xiuping Li,ab   Yan Su,a   Xiaona Li ORCID logo *b  and  Meng Liu ORCID logo *b  

* Corresponding authors

a School of Chemical Engineering, Dalian University of Technology, Liaoning, China

b School of Environmental Science and Technology, Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), Dalian University of Technology, Liaoning 116024, China
E-mail: mliu@dlut.edu.cn, klieee@dlut.edu.cn

Abstract

An integrated origami paper-based analytical device (oPAD) based on competitive enzyme-linked immunosorbent assay (ELISA) was developed for testosterone (TES) detection. In this design, a positive correlation between the signals and analytes was observed due to the connection of the reaction zone and signal readout zone by a “detachable bridge”. The device displayed rapid (35 min), sensitive (LOD: 1 μg L−1) and highly selective characteristics for TES detection. In addition, complex matrices in healthcare food such as oral solutions and tablets showed a negligible effect on the accuracy of this assay (recovery: 95.4–109.1% and RSD < 6%), demonstrating its potential for hazardous chemical testing in real samples.

Graphical abstract: An origami paper-based analytical device for rapid detection of testosterone in healthcare food

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Article information

DOI
https://doi.org/10.1039/D1AY02065J
Article type
Communication
Submitted
05 Dec 2021
Accepted
20 Jan 2022
First published
21 Jan 2022

Anal. Methods, 2022,14, 689-693

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An origami paper-based analytical device for rapid detection of testosterone in healthcare food

X. Li, Y. Su, X. Li and M. Liu, Anal. Methods, 2022, 14, 689 DOI: 10.1039/D1AY02065J

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