Issue 73, 2020, Issue in Progress
From the journal:

RSC Advances

Synthesis of primary N-arylthioglyoxamides from anilines, elemental sulfur and primary C–H bonds in acetophenones†

Khoa M. Tran,ab   Nguyen H. K. Nguyen,ab   Thuy T. Bui,ab   Tuong A. To, ORCID logo ab   Nam T. S. Phan, ORCID logo ab   Ha V. Le*ab  and  Tung T. Nguyen ORCID logo *ab  

* Corresponding authors

a Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam
E-mail: lvha@hcmut.edu.vn, tungtn@hcmut.edu.vn

b Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

Abstract

A simple method for coupling of anilines, acetophenones, and elemental sulfur to afford N-arylthioglyoxamides has been developed. Reactions proceeded in the presence of Na2SO3 and DMSO, thus eliminating the need for transition metals and external oxidants. Functionalities such as halogen, ester, methylthio, and heterocycle groups were compatible with the conditions. Electron-poor acetophenones sometimes gave isosteric glyoxamides.

Graphical abstract: Synthesis of primary N-arylthioglyoxamides from anilines, elemental sulfur and primary C–H bonds in acetophenones

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Article information

DOI
https://doi.org/10.1039/D0RA08740H
Article type
Paper
Submitted
14 Oct 2020
Accepted
07 Dec 2020
First published
18 Dec 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 44743-44746

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Synthesis of primary N-arylthioglyoxamides from anilines, elemental sulfur and primary C–H bonds in acetophenones

K. M. Tran, N. H. K. Nguyen, T. T. Bui, T. A. To, N. T. S. Phan, H. V. Le and T. T. Nguyen, RSC Adv., 2020, 10, 44743 DOI: 10.1039/D0RA08740H

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