Issue 39, 2020, Issue in Progress
From the journal:

RSC Advances

A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug†

Artur Kasprzak, ORCID logo *a   Bartłomiej Dabrowskia  and  Agnieszka Zuchowska ORCID logo a  

* Corresponding authors

a Faculty of Chemistry, Warsaw University of Technology, Noakowskiego Str. 3, 00-664 Warsaw, Poland
E-mail: akasprzak@ch.pw.edu.pl

Abstract

Facile and efficient methods for the synthesis of the first poly(aminodamine) PAMAM G1.0 dendrimer octa-substituted with α-cyclodextrin and a novel ferrocenyl prodrug of doxorubicin hydrochloride are developed. This vector is non-toxic and can bind the designed ferrocenyl prodrug. It also shows a controlled drug release profile and high cytotoxicity against breast cancer cells (MCF-7), as elucidated by the in vitro biological studies performed with an innovative cell-on-a-chip microfluidic system.

Graphical abstract: A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

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Article information

DOI
https://doi.org/10.1039/D0RA03694C
Article type
Paper
Submitted
24 Apr 2020
Accepted
27 May 2020
First published
19 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 23440-23445

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A biocompatible poly(amidoamine) (PAMAM) dendrimer octa-substituted with α-cyclodextrin towards the controlled release of doxorubicin hydrochloride from its ferrocenyl prodrug

A. Kasprzak, B. Dabrowski and A. Zuchowska, RSC Adv., 2020, 10, 23440 DOI: 10.1039/D0RA03694C

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