Issue 4, 2021

Cyclopentane FIT-PNAs: bright RNA sensors

Abstract

Cyclopentane modified FIT-PNA (cpFIT-PNA) probes are reported as highly emissive RNA sensors with the highest reported brightness for FIT-PNAs. Compared to FIT-PNAs, cpFIT-PNAs have improved mismatch discrimination for several pyrimidine–pyrimidine single nucleotide variants (SNVs).

Graphical abstract: Cyclopentane FIT-PNAs: bright RNA sensors

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
10 Nov 2020
Accepted
10 Dec 2020
First published
18 Dec 2020

Chem. Commun., 2021,57, 540-543

Cyclopentane FIT-PNAs: bright RNA sensors

O. Tepper, H. Zheng, D. H. Appella and E. Yavin, Chem. Commun., 2021, 57, 540 DOI: 10.1039/D0CC07400D

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