Issue 12, 2021

Non-genetic cell-surface modification with a self-assembling molecular glue

Abstract

This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the way for translational opportunities for cell therapy.

Graphical abstract: Non-genetic cell-surface modification with a self-assembling molecular glue

Supplementary files

Article information

Article type
Communication
Submitted
29 Oct 2020
Accepted
04 Jan 2021
First published
05 Jan 2021

Chem. Commun., 2021,57, 1470-1473

Non-genetic cell-surface modification with a self-assembling molecular glue

H. Hakariya, I. Takashima, M. Takemoto, N. Noda, S. Sato and M. Uesugi, Chem. Commun., 2021, 57, 1470 DOI: 10.1039/D0CC07171D

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