SCHEDULED MAINTENANCE
Visible light promoted deaminative difluoroalkylation of aliphatic amines with difluoroenoxysilanes†
Jiwei
Gu 
c
and
Chun-Yang
He
*a
c
and
Chun-Yang
He
*a
Abstract
A visible light promoted deaminative strategy for the difluoroalkylation reaction utilizing pyridinium-activated aliphatic primary amines and difluoroenoxysilane as substrates has been developed. This protocol is characteriazed by its mild reaction conditions and broad substrate scope, which converted a diverse array of amine-containing molecules to the alkyl-CF2COPh products. Moreover, the resulting products can be easily transformed into a vast array of structurally novel and interesting difluoro-containing moieties, therefore providing a facile route for applications in medicinal chemistry and the life sciences.
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