Issue 67, 2020
From the journal:

Chemical Communications

The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy†

Frederico R. Baptista,a   Stephen J. Devereux,a   Sarah P. Gurung,bc   James P. Hall, ORCID logo bd   Igor V. Sazanovich,e   Michael Towrie,e   Christine J. Cardin, ORCID logo b   John A. Brazier,d   John M. Kelly ORCID logo f  and  Susan J. Quinn ORCID logo *a  

* Corresponding authors

a School of Chemistry, University College Dublin, Dublin 4, Ireland
E-mail: susan.quinn@ucd.ie

b Department of Chemistry, University of Reading, Whiteknights, Reading, Berks, UK

c Diamond Light Source, Chilton, Didcot, Oxfordshire, UK

d School of Pharmacy, University of Reading, Whiteknights, Reading, Berks, UK

e Central Laser Facility, Rutherford Appleton Laboratory, STFC, Harwell Campus, UK

f School of Chemistry, Trinity College Dublin, Dublin 2, Ireland

Abstract

Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the “light-switch” complex [Ru(phen)2(dppz)]2+1 to i-motif structures in solution. Detailed information is provided due to perturbation of the local base vibrations by a ‘Stark-like’ effect which is used to establish the contribution of thymine base loop interactions to the binding site of 1 in this increasingly relevant DNA structure.

Graphical abstract: The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy

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Article information

DOI
https://doi.org/10.1039/D0CC03702H
Article type
Communication
Submitted
25 May 2020
Accepted
15 Jul 2020
First published
16 Jul 2020

Chem. Commun., 2020,56, 9703-9706

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The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy

F. R. Baptista, S. J. Devereux, S. P. Gurung, J. P. Hall, I. V. Sazanovich, M. Towrie, C. J. Cardin, J. A. Brazier, J. M. Kelly and S. J. Quinn, Chem. Commun., 2020, 56, 9703 DOI: 10.1039/D0CC03702H

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