Issue 7, 1996
From the journal:

Chemical Communications

Improved understanding in platinium antitumour chemistry

Jan Reedijk  

Abstract

After the serendipitous rediscovery of cisplatin{cis-[PtCl2(NH3)2], first synthesized in 1845} in 1964 by Rosenberg, and its routine use as a successful cytostatic durg since 1979, exciting chemistry has resulted from several laboratories, using this simple compound and a variety of its derivatives. The major chemical features that have led to a significant improvement of our insight into the mechanism of action are discussed in this feature acticle. Key elements appear to be: (i) controlled hydrolysis, transport and binding to DNA; (ii) a specific binding at neighbouring guanine bases; and in particular (iii) a specific distortion of DNA, changing its interactions with proteins.

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Article information

DOI
https://doi.org/10.1039/CC9960000801
Article type
Paper

Chem. Commun., 1996, 801-806

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Improved understanding in platinium antitumour chemistry

J. Reedijk, Chem. Commun., 1996, 801 DOI: 10.1039/CC9960000801

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