Issue 13, 2020, Issue in Progress
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RSC Advances

A mild and metal-free synthesis of 2- and 1-alkyl/aryl/dialkyl-aminoquinolines and isoquinolines†

Yerramsetti Nanaji, ORCID logo a   Seema Kirar,b   Sandip V. Pawar ORCID logo *c  and  Ashok Kumar Yadav ORCID logo *c  

* Corresponding authors

a Texas Tech University Health Sciences Center, Ophthalmology Department Lubbock General, 3601 4th Street, Lubbock, TX 79430, USA

b Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S. A. S. Nagar-160062, Punjab, India

c University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
E-mail: pawars@pu.ac.in, ashoky@pu.ac.in

Abstract

A simple synthetic strategy has been developed for the synthesis of 2- and 1-alkyl/aryl/dialkylaminoquinolines and isoquinolines from the easily available quinoline and isoquinoline-N-oxides, different amines, triflic anhydride as activating agent and acetonitrile as solvent in a one-pot reaction under metal-free conditions at 0 °C to room temperature.

Graphical abstract: A mild and metal-free synthesis of 2- and 1-alkyl/aryl/dialkyl-aminoquinolines and isoquinolines

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Article information

DOI
https://doi.org/10.1039/C9RA10397J
Article type
Paper
Submitted
11 Dec 2019
Accepted
30 Jan 2020
First published
20 Feb 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 7628-7634

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A mild and metal-free synthesis of 2- and 1-alkyl/aryl/dialkyl-aminoquinolines and isoquinolines

Y. Nanaji, S. Kirar, S. V. Pawar and A. K. Yadav, RSC Adv., 2020, 10, 7628 DOI: 10.1039/C9RA10397J

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