Issue 53, 2019
From the journal:

RSC Advances

Impact of metallic trace elements on relaxivities of iron-oxide contrast agents

Ji Maa  and  Kezheng Chen ORCID logo *a  

* Corresponding authors

a Lab of Functional and Biomedical Nanomaterials, College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
E-mail: kchen@qust.edu.cn
Fax: +86-532-84022509
Tel: +86-532-84022509

Abstract

In this work, well-defined 3 nm-sized Ca2+, Fe3+, Na+, Mg2+, Zn2+, Ni2+, Co2+, and Cd2+ cation-adsorbed Fe3O4/γ-Fe2O3 nanoparticles were used as prototype systems to investigate the influence of metallic trace elements in body fluids on the relaxivities of iron-oxide contrast agents. It was found that surface-adsorbed cations formed a deterioration layer to induce pronounced relaxivity loss. Theoretical study showed that such relaxivity loss can be well described by a modified GCAS function, taking into account the harmonic cation oscillations around Fe3O4/γ-Fe2O3 nanoparticles. Quantum mechanics analyses revealed that even-parity and odd-parity states of harmonic oscillations are dominant in r1 and r2 relaxivities, respectively. Moreover, the harmonic oscillations of Na+ and Mg2+ cations around Fe3O4/γ-Fe2O3 nanoparticles are found to be classical forbidden, which are quite different from their counterparts located in the classical permissive area.

Graphical abstract: Impact of metallic trace elements on relaxivities of iron-oxide contrast agents

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Article information

DOI
https://doi.org/10.1039/C9RA07227F
Article type
Paper
Submitted
09 Sep 2019
Accepted
23 Sep 2019
First published
30 Sep 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 30932-30936

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Impact of metallic trace elements on relaxivities of iron-oxide contrast agents

J. Ma and K. Chen, RSC Adv., 2019, 9, 30932 DOI: 10.1039/C9RA07227F

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