Multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Shawei Fu; Yadan Ding; Tie Cong; Xiaoguang Yang; Xia Hong; Bo Yu; Yuxin Li; Yichun Liu

doi:10.1039/C9DT02329A

Multifunctional NaYF₄:Yb,Er@PE₃@Fe₃O₄ nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Shawei Fu,^ab Yadan Ding,^a Tie Cong,^a Xiaoguang Yang,^c Xia Hong,

*^a Bo Yu,^a Yuxin Li^d and Yichun Liu^a

Author affiliations

* Corresponding authors

^a Key Laboratory of UV-Emitting Materials and Technology (Northeast Normal University), Ministry of Education, Changchun 130024, P. R. China
E-mail: xiahong@nenu.edu.cn

^b Inorganic Synthesis and Chemical Analysis Institute, Jilin Architectural University, Changchun 130118, P. R. China

^c College of Chemistry, Northeast Normal University, Changchun 130024, P. R. China

^d National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, P. R. China

Abstract

Even though various theranostic agents have been exploited for effective cancer therapy over the years, appropriate design and fabrication of theranostic agents with simple composition, convenient preparation, high theranostic efficiency and minimal side effects on non-cancer cells are still urgently needed. Herein, multifunctional NaYF₄:Yb,Er@polyelectrolyte (PE₃)@Fe₃O₄ nanocomposites, with upconversion luminescence, superparamagnetism and photothermal performance, are prepared by a layer-by-layer self-assembly technique. Compared with Fe₃O₄ nanoparticles (NPs), the nanocomposites exhibited nearly 2-fold strong absorption at 808 nm, and thus resulted in an enhanced near-infrared photothermal effect. With the assistance of an external magnetic field, a high sensitivity of upconversion fluorescence imaging and a low cancer cell viability of 13.9% were achieved under 808 nm laser irradiation. It is expected that multifunctional NaYF₄:Yb,Er@PE₃@Fe₃O₄ nanocomposites would pave the way toward promoting the clinical applications of theranostic nanomaterials.

Article information

https://doi.org/10.1039/C9DT02329A

Article type

Paper

Submitted

03 Jun 2019

Accepted

30 Jul 2019

First published

30 Jul 2019

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Dalton Trans., 2019,48, 12850-12857

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Multifunctional NaYF₄:Yb,Er@PE₃@Fe₃O₄ nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

S. Fu, Y. Ding, T. Cong, X. Yang, X. Hong, B. Yu, Y. Li and Y. Liu, Dalton Trans., 2019, 48, 12850 DOI: 10.1039/C9DT02329A

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Dalton Transactions

Multifunctional NaYF₄:Yb,Er@PE₃@Fe₃O₄ nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

Abstract

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Multifunctional NaYF₄:Yb,Er@PE₃@Fe₃O₄ nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

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