Issue 19, 2020
From the journal:

Chemical Communications

A β-allyl carbamate fluorescent probe for vicinal dithiol proteins†

Lanning Zhao, ORCID logo a   Feifei Bai,a   Fan Chen,a   Menghuan Guo,b   Lu Gan,cde   Hong Zhang ORCID logo cde  and  Jianguo Fang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China
E-mail: fangjg@lzu.edu.cn

b School of Pharmacy Lanzhou University, Lanzhou, Gansu 730000, China

c Department of Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China

d Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, Gansu 730000, China

e University of Chinese Academy of Sciences, Beijing 100039, China

Abstract

The first β-allyl carbamate fluorescent probe, AC-green, was reported for specifically imaging vicinal dithiol proteins (VDPs) in living systems. The probe displays low toxicity and features high sensitivity and fast response towards VDPs. A drastic loss of VDPs in a Parkinson's model was disclosed by AC-green, linking the fluctuation of VDP levels to Parkinson's disease for the first time. The structural novelty and favorable properties of AC-green will advance the development of novel VDP probes.

Graphical abstract: A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC09841K
Article type
Communication
Submitted
19 Dec 2019
Accepted
28 Jan 2020
First published
28 Jan 2020

Chem. Commun., 2020,56, 2857-2860

Permissions

Request permissions

A β-allyl carbamate fluorescent probe for vicinal dithiol proteins

L. Zhao, F. Bai, F. Chen, M. Guo, L. Gan, H. Zhang and J. Fang, Chem. Commun., 2020, 56, 2857 DOI: 10.1039/C9CC09841K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements