Issue 19, 2020
From the journal:

Chemical Communications

Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells†

Mengyi Xiong,a   Meng Zhang,a   Qin Liu,a   Chan Yang,a   Qingji Xie, ORCID logo b   Guoliang Ke,*a   Hong-Min Meng,*c   Xiao-Bing Zhang ORCID logo *a  and  Weihong Tan ORCID logo a  

* Corresponding authors

a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, P. R. China
E-mail: xbzhang@hnu.edu.cn, glke@hnu.edu.cn

b Key Laboratory of Chemical Biology and Traditional Chinese Medicine (Hunan Normal University), Ministry of Education, Changsha 410082, P. R. China

c College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China
E-mail: hmmeng2017@zzu.edu.cn

Abstract

The enzymatic-assisted signal amplification of DNA sensors is rarely applied in living cells due to the difficulties in protein delivery. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.

Graphical abstract: Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC09503A
Article type
Communication
Submitted
07 Dec 2019
Accepted
30 Jan 2020
First published
31 Jan 2020

Chem. Commun., 2020,56, 2901-2904

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Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells

M. Xiong, M. Zhang, Q. Liu, C. Yang, Q. Xie, G. Ke, H. Meng, X. Zhang and W. Tan, Chem. Commun., 2020, 56, 2901 DOI: 10.1039/C9CC09503A

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