Issue 82, 2019

A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery

Abstract

A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(I) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.

Graphical abstract: A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2019
Accepted
16 Sep 2019
First published
27 Sep 2019

Chem. Commun., 2019,55, 12348-12351

A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery

S. Chakravarty, S. J. Sarma, L. N. Goswami, Q. Cai, E. M. Shapiro, M. F. Hawthorne and L. Ma, Chem. Commun., 2019, 55, 12348 DOI: 10.1039/C9CC05383B

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