Issue 63, 2019

Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

Abstract

An umpolung strategy for the cross-coupling of polyfluoroarenes with various substituted hydrazones to construct C(sp2)–C(sp3) bonds is developed. In this strategy, the C–F bond of polyfluoroarenes is cleaved and coupled with moisture- and air-stable hydrazones under mild conditions with good to excellent yields. This method provides a useful tool for synthesizing polyfluorinated pharmaceuticals and functional materials.

Graphical abstract: Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

Supplementary files

Article information

Article type
Communication
Submitted
04 Jun 2019
Accepted
09 Jul 2019
First published
17 Jul 2019

Chem. Commun., 2019,55, 9323-9326

Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

D. Cao, P. Pan, H. Zeng and C. Li, Chem. Commun., 2019, 55, 9323 DOI: 10.1039/C9CC04299G

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