A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging

Chenxia Zhang; Hai Xie; Tongxia Zhan; Jie Zhang; Bochao Chen; Zhaosheng Qian; Guanglu Zhang; Weifen Zhang; Jin Zhou

doi:10.1039/C9CC03909K

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A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging†

Chenxia Zhang,‡^a Hai Xie,‡^b Tongxia Zhan,‡^a Jie Zhang,^a Bochao Chen,^a Zhaosheng Qian,

^c Guanglu Zhang,^d Weifen Zhang^a and Jin Zhou

*^a

Author affiliations

* Corresponding authors

^a College of Pharmacy, College of Nursing, Shandong Engineering Research Center for Smart Materials and Regenerative Medicine, Weifang Medical University, Weifang 261053, China
E-mail: zhoujin@wfmc.edu.cn

^b Affiliated Hospital of Weifang Medical University, Weifang 261031, China

^c College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China

^d College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

Abstract

A new mitochondrion targetable molecular probe for carbon monoxide (CO)-specific detection based on palladium-free mediated opening of spirolactam was designed. The turn-on red fluorescence caused by CO enables a safe and powerful method for unravelling the function of CO in biological systems to be established.

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Article information

DOI: https://doi.org/10.1039/C9CC03909K
Article type: Communication
Submitted: 20 May 2019
Accepted: 01 Jul 2019
First published: 01 Jul 2019

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Chem. Commun., 2019,55, 9444-9447

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A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging

C. Zhang, H. Xie, T. Zhan, J. Zhang, B. Chen, Z. Qian, G. Zhang, W. Zhang and J. Zhou, Chem. Commun., 2019, 55, 9444 DOI: 10.1039/C9CC03909K

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Chemical Communications

A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging†

Abstract

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A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging

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