SCHEDULED MAINTENANCE
Light-controlled thrombin catalysis and clot formation using a photoswitchable G-quadruplex DNA aptamer†
Anna F. A.
Peacock 
a
and
James H. R.
Tucker
*a
a
and
James H. R.
Tucker
*a
Abstract
The reversible photocontrol of an enzyme governing blood coagulation is demonstrated. The thrombin binding aptamer (TBA), was rendered photochromic by modification with two anthracene groups. Light-triggered anthracene photodimerisation distorts its structure, inhibiting binding of the enzyme thrombin, which in turn triggers catalysis and the resulting clotting process.
Please wait while we load your content...
