Issue 7, 2019

Evaluation of novel Griess-reagent candidates for nitrite sensing in aqueous media identified via molecular fingerprint searching

Abstract

The Griess reaction is the most often exploited colorimetric method for the quantitative analysis of nitrite in aqueous media. The application of the currently used reagents are associated with limitations (e.g. linear response range). Herein, molecular fingerprint searching on well-known Griess-reagents was used as a tool for the identification of structurally similar, new reagent candidate molecules. Rapid and high-throughput experimental evaluation of the newly identified Griess-reagent candidates revealed that 14 of the 18 tested reagent candidates had equal or superior response displaying broader linear ranges and/or increased response gradient against various nitrite concentrations in aqueous media when compared to the parent compounds at room temperature.

Graphical abstract: Evaluation of novel Griess-reagent candidates for nitrite sensing in aqueous media identified via molecular fingerprint searching

Supplementary files

Article information

Article type
Paper
Submitted
14 Sep 2018
Accepted
16 Jan 2019
First published
29 Jan 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 3994-4000

Evaluation of novel Griess-reagent candidates for nitrite sensing in aqueous media identified via molecular fingerprint searching

L. Váradi, M. Breedon, F. F. Chen, A. Trinchi, I. S. Cole and G. Wei, RSC Adv., 2019, 9, 3994 DOI: 10.1039/C8RA07656A

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