Issue 60, 2018, Issue in Progress
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RSC Advances

Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms†

Hamad M. Al-Matar, ORCID logo *a   Kamal M. Dawood ORCID logo *b  and  Wael M. Tohamy ORCID logo c  

* Corresponding authors

a Chemistry Department, Faculty of Science, University of Kuwait, P. O. Box 5969, Safat 13060, Kuwait
E-mail: h.almatar@ku.edu.kw
Fax: +965 24816482
Tel: +965 24987559

b Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt
E-mail: dr_dawood@yahoo.com
Fax: +20 235727556
Tel: +20 235676602

c Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt

Abstract

Several 2-arylcinnolin-6(2H)-one derivatives were synthesized via tandem annulation of a large number of 3-oxo-2-arylhydrazonopropanals with acetoacetanilide under three different heating modes (conventional heating, ultrasound and microwave irradiation) using triethylamine in ethanol. The factors affecting the optimization of the annulation process were thoroughly studied. The annulated structures were established on the basis of 1H and 13C NMR and MALDI-TOF/MS spectral data as well as single crystal X-ray analysis.

Graphical abstract: Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms

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Article information

DOI
https://doi.org/10.1039/C8RA06494F
Article type
Paper
Submitted
01 Aug 2018
Accepted
28 Sep 2018
First published
08 Oct 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 34459-34467

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Tandem one-pot synthesis of 2-arylcinnolin-6-one derivatives from arylhydrazonopropanals and acetoacetanilides using sustainable ultrasound and microwave platforms

Hamad M. Al-Matar, K. M. Dawood and W. M. Tohamy, RSC Adv., 2018, 8, 34459 DOI: 10.1039/C8RA06494F

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