Reversible redox inter-conversion of biologically active NAD+/NADH derivatives bound to a gold electrode: ToF-SIMS evidence

Ruo-Can Qian; Li-Jun Zhao; Jian Lv; Xin Hua; Yi-Tao Long

doi:10.1039/C8CC08341J

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Reversible redox inter-conversion of biologically active NAD⁺/NADH derivatives bound to a gold electrode: ToF-SIMS evidence†

Ruo-Can Qian,

‡^a Li-Jun Zhao,‡^a Jian Lv,^a Xin Hua

^a and Yi-Tao Long

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, P. R. China
E-mail: ytlong@ecust.edu.cn

Abstract

The realization of the reversible inter-conversion between NADH and NAD⁺ is a long-term challenge in biological and energy-related chemistry. Here, we achieve the electrochemical reversible redox of NAD⁺/NADH derivatives by the functionalization of a gold electrode with a specially designed NAD⁺ derivative, and the electrochemical redox products are characterized by time-of-flight secondary ion mass spectrometry (ToF-SIMS).

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Article information

DOI: https://doi.org/10.1039/C8CC08341J
Article type: Communication
Submitted: 18 Oct 2018
Accepted: 13 Nov 2018
First published: 14 Nov 2018

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Chem. Commun., 2018,54, 13945-13948

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Reversible redox inter-conversion of biologically active NAD⁺/NADH derivatives bound to a gold electrode: ToF-SIMS evidence

R. Qian, L. Zhao, J. Lv, X. Hua and Y. Long, Chem. Commun., 2018, 54, 13945 DOI: 10.1039/C8CC08341J

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