Issue 92, 2018
From the journal:

Chemical Communications

Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts†

Naresh Gunaganti, ORCID logo a   Anupreet Kharbanda,a   Naga Rajiv Lakkaniga,a   Lingtian Zhang,a   Rose Cooper,a   Hong-yu Li*a  and  Brendan Frett ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, USA
E-mail: BAFrett@uams.edu, HLi2@uams.edu

Abstract

Multicomponent reactions (MCRs) are robust tools for the rapid synthesis of complex, small molecule libraries for use in drug discovery and development. By utilizing MCR chemistry, we developed a protocol to functionalize the C-3 position of imidazo[1,2-a]pyridine through a three component, decarboxylation reaction involving imidazo[1,2-a]pyridine, glyoxalic acid, and boronic acid.

Graphical abstract: Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

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Article information

DOI
https://doi.org/10.1039/C8CC07063F
Article type
Communication
Submitted
31 Aug 2018
Accepted
22 Oct 2018
First published
23 Oct 2018

Chem. Commun., 2018,54, 12954-12957

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Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

N. Gunaganti, A. Kharbanda, N. R. Lakkaniga, L. Zhang, R. Cooper, H. Li and B. Frett, Chem. Commun., 2018, 54, 12954 DOI: 10.1039/C8CC07063F

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