Sensing caspase-1 activity using activatable 19F MRI nanoprobes with improved turn-on kinetics

Kazuki Akazawa; Fuminori Sugihara; Masafumi Minoshima; Shin Mizukami; Kazuya Kikuchi

doi:10.1039/C8CC05381B

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Sensing caspase-1 activity using activatable ¹⁹F MRI nanoprobes with improved turn-on kinetics†

Kazuki Akazawa,^a Fuminori Sugihara,^b Masafumi Minoshima,^a Shin Mizukami^c and Kazuya Kikuchi

*^ab

Author affiliations

* Corresponding authors

^a Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
E-mail: kkikuchi@mls.eng.osaka-u.ac.jp

^b WPI-Immunology Frontier Research Center, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

^c Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan

Abstract

Activatable ¹⁹F MRI nanoprobes for sensing caspase-1 activity were developed. Tandem repetition of substrate peptide sequences improved the turn-on response of nanoprobes, allowing detection of caspase-1 activity by ¹⁹F MRI. In vivo immune response was successfully imaged using the new nanoprobe.

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Article information

DOI: https://doi.org/10.1039/C8CC05381B
Article type: Communication
Submitted: 04 Jul 2018
Accepted: 08 Aug 2018
First published: 02 Oct 2018
This article is Open Access

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Chem. Commun., 2018,54, 11785-11788

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Sensing caspase-1 activity using activatable ¹⁹F MRI nanoprobes with improved turn-on kinetics

K. Akazawa, F. Sugihara, M. Minoshima, S. Mizukami and K. Kikuchi, Chem. Commun., 2018, 54, 11785 DOI: 10.1039/C8CC05381B

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