A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

Peng-Fei Cui; Wan-Ru Zhuang; Xi Hu; Lei Xing; Ru-Yi Yu; Jian-Bin Qiao; Yu-Jing He; Fangyuan Li; Daishun Ling; Hu-Lin Jiang

doi:10.1039/C8CC04363A

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units†

Peng-Fei Cui,‡^abcd Wan-Ru Zhuang,‡^a Xi Hu,

‡^e Lei Xing,^abcd Ru-Yi Yu,^a Jian-Bin Qiao,^a Yu-Jing He,^a Fangyuan Li,^e Daishun Ling

*^e and Hu-Lin Jiang

*^abcd

Author affiliations

* Corresponding authors

^a State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
E-mail: jianghulin3@163.com

^b Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China

^c Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China

^d Jiangsu Key Laboratory of Drugaability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, China

^e State Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
E-mail: lingds@zju.edu.cn

Abstract

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π–π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.

Chemical Communications

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units†

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A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

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