Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012

Zhiqiang Zhang; Xingkang Wu; Rentai Song; Juanli Zhang; Haoxin Wang; Jing Zhu; Chunhua Lu; Yuemao Shen

doi:10.1039/C7RA00961E

Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012†

Zhiqiang Zhang,^a Xingkang Wu,^a Rentai Song,^b Juanli Zhang,^c Haoxin Wang,^b Jing Zhu,^b Chunhua Lu^a and Yuemao Shen

*^ab

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* Corresponding authors

^a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, P. R. China
E-mail: yshen@sdu.edu.cn
Tel: +86-531-88382108

^b State Key Laboratory of Microbial Technology, Shandong University, No. 27 South Shanda Road, Jinan, Shandong 250100, P. R. China

^c Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi 710032, P. R. China

Abstract

Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. In this study, four new polyketides of ansamycin class, designated as ansavaricins F–I (1–4), were obtained from the Streptomyces sp. S012 strain. All the compounds were structurally characterized as open-chain streptovaricin derivatives by using NMR and HRESIMS techniques, and showed different degrees of inhibition against human DNA topoisomerases. Ansavaricin H is a promising lead for the development of new inhibitors of human DNA topoisomerases.

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DOI: https://doi.org/10.1039/C7RA00961E
Article type: Paper
Submitted: 22 Jan 2017
Accepted: 02 Mar 2017
First published: 07 Mar 2017
This article is Open Access

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RSC Adv., 2017,7, 14857-14867

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Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012

Z. Zhang, X. Wu, R. Song, J. Zhang, H. Wang, J. Zhu, C. Lu and Y. Shen, RSC Adv., 2017, 7, 14857 DOI: 10.1039/C7RA00961E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012†

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Ansavaricins F–I, new DNA topoisomerase inhibitors produced by Streptomyces sp. S012

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