Issue 16, 2017
From the journal:

Organic & Biomolecular Chemistry

A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones†

Chao Lin,a   Hong-Jin Du,a   Hui Zhao,a   Ding-Fei Yan,a   Nai-Xin Liu,a   Hongbin Sun,a   Xiaoan Wen*a  and  Qing-Long Xu ORCID logo *a  

* Corresponding authors

a Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China
E-mail: wxagj@126.com, qlxu@cpu.edu.cn

Abstract

A formal [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones was realized to furnish polycyclic indolines in good yields. This protocol proceeded smoothly under basic conditions, with high atom-economy and broad substrate scope.

Graphical abstract: A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

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Article information

DOI
https://doi.org/10.1039/C7OB00392G
Article type
Paper
Submitted
17 Feb 2017
Accepted
28 Mar 2017
First published
28 Mar 2017

Org. Biomol. Chem., 2017,15, 3472-3478

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A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

C. Lin, H. Du, H. Zhao, D. Yan, N. Liu, H. Sun, X. Wen and Q. Xu, Org. Biomol. Chem., 2017, 15, 3472 DOI: 10.1039/C7OB00392G

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