Issue 9, 2017
From the journal:

Nanoscale

DNA photonic nanowires with tunable FRET signals on the basis of toehold-mediated DNA strand displacement reactions†

Bei Wang,‡a   Xiaojing Wang,‡a   Bing Wei,b   Fujian Huang,*c   Dongbao Yaoa  and  Haojun Liang*ab  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China
E-mail: hjliang@ustc.edu.cn

b Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, People's Republic of China

c Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan 430074, People's Republic of China
E-mail: huangfj@cug.edu.cn

Abstract

A DNA photonic nanowire with tunable FRET signals was fabricated on the basis of cascaded toehold-mediated DNA strand displacement reactions. Different DNA inputs were added to trigger the reaction network, and the corresponding FRET signals were obtained. Compared to the direct hybridization, this design is sensitive for 2 nM targets within 20 min and also causes color changes of the solution with blue-light excitation. It could also be applied in live cells to monitor MicroRNA with a simple modification which might become a low-cost method for further application in the future.

Graphical abstract: DNA photonic nanowires with tunable FRET signals on the basis of toehold-mediated DNA strand displacement reactions

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Article information

DOI
https://doi.org/10.1039/C7NR00386B
Article type
Communication
Submitted
17 Jan 2017
Accepted
02 Feb 2017
First published
09 Feb 2017

Nanoscale, 2017,9, 2981-2985

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DNA photonic nanowires with tunable FRET signals on the basis of toehold-mediated DNA strand displacement reactions

B. Wang, X. Wang, B. Wei, F. Huang, D. Yao and H. Liang, Nanoscale, 2017, 9, 2981 DOI: 10.1039/C7NR00386B

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