The speed-up of covalent bond formation was achieved between a sulfhydryl group and a 2-bromopropionic acid derivative by utilizing sliding peptide-modified substrates. Moreover, a new type of DNA cleaving reagent was developed, consisting of pVIc covalently coupled to verteporfin. This peptide–porphyrin conjugate allowed targeting of DNA and resulted in increased photodegradation of double-stranded nucleic acids.
L. Zhang, L. Zheng, Z. Meng, K. Balinin, M. Loznik and A. Herrmann, Chem. Commun., 2017, 53, 6331 DOI: 10.1039/C7CC02500A
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