We developed activography to map enzymatic activities on tissue sections using activity-based probes. The assay was validated using a new protease-activity probe on skin biopsies to provide proof-of-concept. Activography is more selective and technically easier than the established in situ zymography, thus, adaptable in routine running clinico-chemical laboratories.
G. Pampalakis, E. Zingkou, K. Vekrellis and G. Sotiropoulou, Chem. Commun., 2017, 53, 3246 DOI: 10.1039/C7CC01081H
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